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Naltrexone to drink less

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Oar Health prescribes naltrexone online and advertises it as a way to “freeze your alcohol cravings”, with 73% of members drinking less within two weeks. Short answer: naltrexone is one of the best-tested medicines for alcohol use disorder — pooled placebo-controlled trials found fewer people returned to heavy drinking. The 73% is Oar’s own number, not a trial result. It is a prescription medicine, so a clinician has to check it is safe for you; Oar’s own page warns it must not be taken by anyone using opioids.

How the evidence flows

Flowchart for this page: each claim, the studies that tested it and what they found, and the grade that follows. The same studies and grades are listed in full below.

Each claim (middle), the studies that tested it (left) — green found it, red found nothing — and the grade they add up to (right). Drawn from the same records as the grades below. Tap to open full size.

Naltrexone for drinking less (Oar) · evidence checked 2026-10-27

What the research shows

Grades are calculated from the studies listed, by fixed rules.

  • Naltrexone (50 mg a day) helps people with alcohol use disorder drink lessEstablished

    Pooled placebo-controlled trials of 12 weeks or more found fewer people returned to heavy drinking on naltrexone; about 11 people need treating for one to benefit. Nausea and vomiting were more common. The review supports it alongside counselling, not instead of it.

    • Pooled analysis of randomized trials, 20,976 people (2023) — primary outcome: improved. Funder not checked.
  • With Oar, 73% drink less within 2 weeksNo real evidence
    The ad said
    “Freeze your alcohol cravings / 50,000+ Treated / 73% Drink Less In 2 Weeks”

    Oar Health · Facebook ad, seen Oct 2026

    The 73% is Oar’s own figure about its members, not a trial with a comparison group, and the trials above ran 12 weeks or more. Oar’s own page says naltrexone must not be taken by anyone using opioids, and that its under-the-tongue “Clutch” mint is a compounded medication not reviewed by the FDA.